Zerr lab

Patients with heart failure have an increased risk of developing cognitive decline and the risk of dementia increases with increasing severity of heart failure. Cardiac decompensation in particular leads to a temporary worsening of heart failure. This is also reproducible in mouse models, so that the correlation between heart failure and cognitive dysfunction is not due to confounding factors such as globally increased cardiovascular risk, but rather there appears to be a direct link between heart failure and cognitive function. Through the joint study of cardiology and neurology, we want to gain a better understanding of the connection in order to be able to intervene therapeutically at an early stage. The study involves two cohorts - patients with heart failure and patients with aortic valve stenosis and planned TAVI. In both groups, cognitive and cardiac function will be examined longitudinally in order to draw conclusions about the relationship between cardiac function and cognitive function and to develop predictive biomarkers.